The British Journal of Experimental Pathology, Vol. 1 (Classic Reprint)
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Produktbeschreibung
Excerpt from The British Journal of Experimental Pathology, Vol. 1 The question seemed worth some further investigation. We may first consider the results of mere defibrination of the blood. It is well known that the re-injection of defibrinated blood of a rabbit, even into the same animal from which it was taken, is followed by death. This was found to be explained by the production of intravascular clotting. Whether this is due to the exceptional properties of rabbits blood or to a peculiar propensity of this animal to intravascular clotting is difficult to decide, on account of the toxic properties of blood from a different species in the case of animals in general, Brodie (1) ascribed these toxic properties to a protein in the serum produced in the act of coagulation. It is to be noted, however, that the remarkable properties of foreign proteins, of which anaphylaxis is one manifestation, were unknown at the time of his experiments, only one of which consisted of the injection into a cat of its own defibrinated blood. All the others were with foreign serum. I am inclined to attribute the toxic action obtained in the one case of the defibrinated blood of the cat itself to some accidental circumstance, since I have not met with it in a large number of experiments in which the defibrinated blood of the same or another cat was injected for various purposes. We may conclude that, with the exception of the rabbit, which is peculiarly sensitive to the "fibrin-ferment" produced in clotting, the re-injection of defibrinated blood into the animal itself is harmless. Whether man does or does not behave like the rabbit I am unable to say, not having met with any case in which defibrinated blood has been injected. It appears, however, from some remarks by Quenu (2), that blood-serum has been used in the French Army for the treatment of wound-shock. But no data are given as to the results. We may pass on to the more interesting problem of hæmolysis. Couvreur and Clement (3) describe experiments in which they re-injected rabbit´s blood, after the corpuscles had been laked, into the same animal from which the blood had been taken. It is unfortunate, for the reason given above, that rabbits were used, and the description of the manner of death - convulsions, with a loud cry - suggests that intravascular clotting had been produced. It is true that one experiment is given in which the serum of clotted blood was innocuous, but it is to be remembered that individual rabbits may be met with in which the phenomenon of intravascular clotting is absent. Mudge (4), indeed, states that albino rabbits are refractory in this respect; but it is doubtful whether his experiments were sufficiently numerous to warrant a general statement. An experiment made by Paul Bert (5) is given by himself as a proof that hæmoglobin freed from the corpuscles is toxic. A dog was bled until rigidity of the limbs came on. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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