The Journal of Experimental Medicine, Vol. 34
| Preis: | 14.95 EUR* (inkl. MWST zzgl. Versand - Preis kann jetzt höher sein!) |
| Versand: | 0.00 EUR Versandkostenfrei innerhalb von Deutschland |
| Partner: | buecher.de |
| Hersteller: | Forgotten Books (Flexner, Simon) |
| Stand: | 2015-08-04 03:50:33 |
Produktbeschreibung
Excerpt from The Journal of Experimental Medicine, Vol. 34: December 1, 1921; Studies on the Treatment of Human Trypanosomiasis With Tryparsamide (the Sodium Salt of N-Phenylglycineamide-P-Arsonic Acid) The work in experimental chemotherapy of certain protozoan infections which has been in progress at the Rockefeller Institute for several years, has resulted in the development of a large series of compounds, of which one at least was found to possess a high degree of therapeutic activity in experimental trypanosomiasis. This substance, N-phenylglycineamide-p-arsonic acid, was first made in 1915 by Dr. Walter A. Jacobs and Dr. Michael Heidelberger (1 and 2) and studied biologically in collaboration with Dr. Wade H. Brown under its serial number of A 63; its sodium salt has recently been named "Tryparsamide." The biological investigations included toxicologic experiments (3) in which it was shown that the reaction of different species of laboratory animals to the drug was of a favorable character. The substance lends itself well to almost any method of administration and can be given to animals in large doses. Moreover, toxic effects were confined to doses relatively close to the minimum lethal dose and the recovery of animals from sublethal intoxication was remarkably rapid and complete, thus making possible the repetition of large doses at comparatively short intervals of time. The therapeutic activity of the drug in experimental trypanosomiasis (4) was particularly evidenced by the relative speed and sharpness of action in the acute blood infections of mice and rats and by the potency and duration of action in the subacute and chronic tissue infections of guinea pigs and rabbits. The accomplishment of a permanent cure was obtained in the experimental infections produced by five strains of pathogenic trypanosomes, Tr. brucei, Tr. gambiense, Tr. evansi, Tr. equiperdum, and Tr. equinum, but, on the other hand, infections produced by Tr. rhodesiense were more difficult to influence (5). Comparative experiments in laboratory animals with well known drugs such as atoxyl, arsacetin, arsenophenylglycin, salvarsan, neosalvarsan, luargol, and galyl, all of which have been used in the treatment of human trypanosomiasis, showed that tryparsamide was in many respects their superior. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
* Preis kann jetzt höher sein. Den aktuellen Stand und Informationen zu den Versandkosten finden sie auf der Homepage unseres Partners.
Folgende Produkte könnten dir ebenso gefallen
