E. Merck´s Annual Report, Vol. 27
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Excerpt from E. Merck´s Annual Report, Vol. 27: Of Recent Advances in Pharmaceutical Chemistry and Therapeutics Nuclein and lecithin, two compounds of phosphorus of considerable biological importance to the plant and animal organism, have for many years past engaged the attention of therapeutists. Lecithin was dealt with in my Annual Report for 1912; the following notes are devoted to a consideration of nuclein and nucleinic acid. In the first place, it is necessary to establish a clear definition of the terms nuclein and nucleinic acid, as I have found from experience that both terms are sometimes regarded as synonymous. Particularly the term nuclein is frequently employed instead of nucleinic acid, probably because the former is the shorter expression. Nuclein, however, as yet occupies a relatively unimportant place in therapeutics, and it is nucleinic acid which during the past few years has grown in medical interest. The statement made above regarding the importance of nuclein to the organism must be taken cum grano salis, for in the living cell, or rather in the nucleus which is so closely connected with cell-division, no nuclein, but a nucleo-proteid is present. The nucleins are degradation products of the nucleo-proteids, and are formed from the latter, inter alia, by the splitting off of albumin, e. g., by digesting with pepsin-hydrochloric acid. The nucleo- proteids are first of all converted into nucleins, and after giving up more albumin, into nucleinic acids. The chemical relationship of these bodies may be represented as follows: nucleinic acid in combination with one part of albumin forms a nuclein, and with two parts of albumin, a nucleo-proteid. As the nucleins never occur as such in the nucleus, but are to a certain extent artificial products, Hammarsten suggested the rejection of the term "nucleins" in favour of the expression "denaturated nucleo-proteids." About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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