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Annual of the Universal Medical Sciences, 1896, Vol. 5 (Classic Reprint)




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Excerpt from Annual of the Universal Medical Sciences, 1896, Vol. 5 Absorption and Elimination of Drugs by the Stomach. - The influence of age and sexual life on the rapidity with which certain drugs are absorbed in the stomach of the healthy woman has been studied by W. P. Demidowitch, who made 131 experiments on 49 female subjects varying in age from 8 to 60 years. Iodide of potassium and salicylate of sodium were each used for 49 experiments, and 23 control experiments were made. Absorption of both drugs by the stomach was found to take place more rapidly in little girls than in elderly women; but, while there were no marked variations in infancy or old age, the variations were marked in women during the menstrual epoch. Iodine appeared in the saliva two or three minutes sooner than in the urine, generally at the end of 11.8 minutes in the saliva and 14.3 in the urine. Salicylate of sodium appeared in the saliva in 13.7 minutes. In 7 cases resorption was accelerated a few days before menstruation, in 3 cases in the first days of the menstrual period; while in all cases it was retarded toward the end of the period, gradually increasing afterward. Both drugs were more rapidly absorbed in pregnant than in non-pregnant women of the same age, increasing as pregnancy advanced. It was also more rapid in proportion to the number of previous pregnancies. The elimination of medicinal substances by the gastric mucous membrane forms the subject of a lengthy paper by Paul Binet, of Geneva, who states that the gastric mucous membrane normally eliminates a large quantity of chlorine, especially under the form of free hydrochloric acid during digestion or in the slate of the alkaline chlorides. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.


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