American Journal of Pharmacy, 1876, Vol. 6 (Classic Reprint)
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Produktbeschreibung
Excerpt from American Journal of Pharmacy, 1876, Vol. 6 In 1872, Dr. Peugnet Med. Rec. May, 1872, p. 121) also concluded that the veratroida of Bullock was distinct from veratria, as it did not respond, to the sulphuric acid test for that base, although it did to Trapp stest (hydrochloric acid). And he was the first to announce that Bullock´s viridia was identical with Simon´s jervia of Veratrum album. So, in 1874, Mr. C.L. Mitchell (Proc. Am. Phar. Asso., 1874, p 436,) obtained from this plant a base readily soluble in ether, which failed to fully respond both to the sulphuric and hydrochloric acid tests for veratria, and he therefore concluded that it was a distinct principle. Mr. Mitchell confirmed Dr. Peugnet´s announcement of the identity of viridia and jervia. Much the same confusion has existed in regard to the principal alkaloid of Veratrum album. Thus, in 1819, Pelletier and Caventou announced that the alkaloid of the plant was identical with veratria from sabadilla seeds; whilst, in 1872, Dr. Peugnet claimed that the alkaloid was not veratria, but identical with veratroidia of Veratrum viride; whilst still later, Mr. C. L. Mitchell claimed that it differed from both alkaloids and proposed for it the name veratralbia. The question as to the identity, or otherwise of these principles being a matter of considerable importance, especially in toxicological examinations, we have given the subject very careful study, and, as the result of repeated experiments, we find that both veratrum viride and veratrum album contain an alkaloid which when pure in its behavior with the mineral acids and with liquid precipitants fully responds to all the reactions of veratria or veratrin. Thus in the solid state, under the action of concentrated sulphuric acid, the alkaloid from both plants assumes a yellow color, and slowly dissolves to a yellow or reddish-yellow solution, which after a time becomes orange red and finally deep crimson with a purplish hue. If the mixture be gently warmed, the crimson coloration manifests itself at once. If the alkaloid is impure, at least, if it contains an apparently oily matter which adheres most tenaciously, it will strike a more or less red color with sulphuric acid and quickly dissolve to a reddish-yellow solution, which after a time acquires a more or less brownish-red color but fails to assume the crimson coloration of the pure alkaloid. The presence of pure jervia in very minute quantity does not appear to materially interfere with the normal reaction of the alkaloid with this acid. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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