Role of neuronal IGF-1R signaling in Alzheimer´s disease
| Preis: | 53.90 EUR* (inkl. MWST zzgl. Versand - Preis kann jetzt höher sein!) |
| Versand: | 0.00 EUR Versandkostenfrei innerhalb von Deutschland |
| Partner: | buecher.de |
| Hersteller: | Südwestdeutscher Verlag Für Hochschulschriften (Hettich, Moritz M.) |
| Stand: | 2015-08-04 03:50:33 |
Produktbeschreibung
Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced Aß accumulation. In addition Aß plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced Aß accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer´s disease is most likely a compensatory phenomenon.
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